The research interests of the applicant focus on two critical areas in cancer research: developing innovative therapeutic approaches to overcome resistance to cancer immunotherapy; and identifying genetic and epigenetic abnormalities in cancers and pre-cancers. He has authored 71 manuscripts in international journals, over half of them were published in journals with impact factor >10. He also served as an invited ad hoc reviewer and reviewed over 440 manuscripts for 131 international journals. Over the past two years, he has successfully secured more than 2.2 million SGD in research funding as the Principal Investigator (PI), and 3.5 million SGD as Co-Investigator and Collaborator. He also contributes as a Team Principal Investigator to a large CRP (Competitive Research Programme) grant from NRF. He was the recipient of the prestigious Lee Kuan Yew Postdoctoral Fellowship and the Year 2021 Gilead Research Scholars Award (Hematology and Oncology).

Selected recent publications (up to 10):
1. Xue-Bin Ran, Ling-Wen Ding (Co-Corresponding author), Qiao-Yang Sun, et al. Targeting RNA exonuclease XRN1 potentiates efficacy of cancer immunotherapy. Cancer Research, 2023. IF=13.312
2. Xin-Yi Loh, Qiao-Yang Sun, Ling-Wen Ding (Corresponding author), et al. RNA-binding protein ZFP36L1 suppresses hypoxia and cell cycle signaling. Cancer Research 2020; 80 (2), 219-233. IF=13.312
3. Ling-Wen Ding, Qiao-Yang Sun, Jarem J Edwards, et al. LNK suppresses interferon signaling in melanoma. Nature Communications 2019; 10(1):2230. IF=17.694
4. Qiao-Yang Sun, Ling‐Wen Ding (Corresponding author), Kara Johnson, et al. SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells. Oncogene 2019; 38(34):6196-6210. IF=8.756
5. Zhen-Tang Lao, Ling‐Wen Ding (Corresponding author), Omer An, et al. Mutational and transcriptomic profiling of acute leukemia of ambiguous lineage reveals obscure but clinically important lineage bias. Haematologica 2019; 104(5):e200-e203. IF=11.047
6. Jin‐Fen Xiao, Qiao‐Yang Sun, Ling‐Wen Ding (Corresponding author), et al. The MYC/BMI1 axis is essential for SETDB1‐mediated breast tumorigenesis. The Journal of Pathology 2018; 246 (1), 89-102. IF=9.883
7. Ling-Wen Ding, Qiao-Yang Sun, Kar-Tong Tan, et al. Mutational landscape of pediatric acute lymphoblastic leukemia. Cancer Research 2017; 15;77(2):390-400. IF=13.312
8. Ling-Wen Ding, Qiao-Yang Sun, Anand Mayakonda, et al. Mutational profiling of acute lymphoblastic leukemia with testicular relapse. Journal of Hematology & Oncology 2017; 2; 10(1):65-69. IF=23.168
9. Ling-Wen Ding, T Ikezoe, KT Tan, et al. Mutational profiling of a MonoMAC syndrome family with GATA2 deficiency. Leukemia 2017; 31(1): 244–245. IF=12.883
10. Qiao-Yang Sun, Ling-Wen Ding (Corresponding author), Kar-Tong Tan, et al. Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD). Leukemia 2017;31(1):1-10. IF=12.883