Assoc Prof Mathuru is interested in understanding the neural, genetic, and molecular mechanisms underlying animal behaviour. Using a small, translucent vertebrate (zebrafish) that allows one to perform precise genetic manipulations and optical imaging of neural activity at a high resolution, his laboratory develops new tools to study and analyse natural behaviours motivated by rewards and risks – such as social behaviours, predator avoidance, and behaviours triggered by appetitive, or aversive, or olfactory cues.
They then apply their findings to understand the neurogenetics of human disorders of the brain. Current studies examine genes implicated in addiction, anxiety disorders, depression, epilepsy, and neurodegeneration in humans.